Christine Gregory graduated from the University of Michigan Law School in 1996. She began her career in Washington, D.C., as a staff attorney for the Neighborhood Legal Services Program where her practice areas included landlord-tenant litigation, public benefits, and family law. In 2000, she was hired as the executive director of the Urban Alliance Foundation, a nonprofit organization dedicated to providing disadvantaged high school students with career-focused internships and access to college. During her time at the Urban Alliance Foundation she established the Health Alliance project, a public-assistance-to-paid-employment initiative that provided inroads for low-income young adults to pursue professional nursing careers.

Dean Gregory was appointed the assistant dean for student affairs in October 2007. In this capacity she leads diversity and inclusion initiatives at the Law School and was awarded the University of Michigan's Distinguished Diversity Leaders Award in 2012. She co-created and co-taught a cross-cultural lawyering seminar and leads workshops on cultural competency within the legal profession. In 2011, she transitioned MAP (Michigan Access Program), the Law School's longstanding diversity program, into a social justice leadership initiative for incoming first-year students.

In addition to diversity and inclusion efforts, Dean Gregory's other primary responsibilities include advising student organizations, overseeing academic support efforts, administering dual degree and externship programming, and providing general academic counseling and advice to students.

Prior to assuming the role of assistant dean for student affairs, she worked as an attorney-counselor in the Office of Career Services at the Law School.